Yun Ding Email & Phone Number | I have played a key role in the DNA-encoded library technology platform in GSK & Praecis. • Managed a team of scientists focusing on the “on-DNA” chemistry development, library design and synthesis; • Lead the development of new generation of DNA-encoded library technology. • Hit confirmation and hit-to-lead optimization of hits from ELT selection. Delivered the first drug candidate from ELT. Representative publications on Encoded Library Technology (ELT): 1. Mantell, M. A.; Marcaurelle, L.; Ding, Y. One Reaction Served Three Ways: The on-DNA Ugi 4C-3C Reation for the Formation of Lactams. Org. Lett., 2023, 25(8), 1241-1245. 2. Ling, X.; et al.; Ding, Y.;* Lu, X.* Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations. Bioconjugate Chem., 2023, 34(4), 616-620. 3. Ding, Y.;* Belyanskaya, S. L.; et al. Discovery of Soluble Expoxide Hydrolase Inhibitors through DNA-encoded library technology (ELT). Bioorg. & Med. Chem., 2021, 41, 116216-116224. 4. Yuen, J.; Chai, J.; Ding, Y.* Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones on DNA. Bioconjugate Chem. 2020, 31(12), 2712-2718. 5. Ding, Y.;* Chai, J.; et al. Development and Synthesis of DNA-Encoded Benzimidazole Library. ACS Comb. Sci. 2018, 20(5), 251-255. 6. Ding, Y.;* DeLorey, J. L.; Clark, M. A. “Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides”, Bioconjugate Chem., 2016, 27(11), 2597-2600. 7. Ding, Y.;* Franklin, G. J.; et al. “Design and Synthesis of Bi-Aryl DNA-encoded Libraries”, ACS Comb. Sci., 2016, 18, 625-629. 8. Ding, Y.;* O’Keefe, H.; et al. “Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-encoded Library Technology (ELT)” ACS Med. Chem. Lett., 2015, 6, 888–893. 9. Clark, M. A.; et al “Design, Synthesis and Selection of DNA-Encoded Small-molecule Libraries” Nat. Chem. Bio. 2009, 5, 647-654. Patents: 1. Ding, Y. PCT Int. Appl. (2010), WO 2010085246 2. Ding, Y.; Thalji, R. K.; Marino, J. P. PCT Int. Appl. (2009), WO 200949157. 3. Ding, Y.; Thalji, R. K.; Marino, J. P. PCT Int. Appl. (2009), WO 2009049165. 4. Ding, Y.; Longdregan, A. T.; Marino, J. P. PCT Int. Appl. (2009), WO 2009049154. 5. Ding, Y.; Marino, J. P.; Li, P.; Longdregan, A. T. PCT Int. Appl. (2008), WO 2008105968. Specialties: DNA-encoded library technology, synthetic chemistry, medicinal chemistry, combinatorial chemistry, high-throughput screening, drug discovery

Yun Ding

I have played a key role in the DNA-encoded library technology platform in GSK & Praecis. • Managed...
Cambridge, Cambridge, United States

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Associate Director, Gsk Fellow

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Praecis

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2004-02-01 00:00:00 - 2007-02-01 00:00:00

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Yun Ding is a I have played a key role in the DNA-encoded library technology platform in GSK & Praecis. • Managed a team of scientists focusing on the “on-DNA” chemistry development, library design and synthesis; • Lead the development of new generation of DNA-encoded library technology. • Hit confirmation and hit-to-lead optimization of hits from ELT selection. Delivered the first drug candidate from ELT. Representative publications on Encoded Library Technology (ELT): 1. Mantell, M. A.; Marcaurelle, L.; Ding, Y. One Reaction Served Three Ways: The on-DNA Ugi 4C-3C Reation for the Formation of Lactams. Org. Lett., 2023, 25(8), 1241-1245. 2. Ling, X.; et al.; Ding, Y.;* Lu, X.* Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations. Bioconjugate Chem., 2023, 34(4), 616-620. 3. Ding, Y.;* Belyanskaya, S. L.; et al. Discovery of Soluble Expoxide Hydrolase Inhibitors through DNA-encoded library technology (ELT). Bioorg. & Med. Chem., 2021, 41, 116216-116224. 4. Yuen, J.; Chai, J.; Ding, Y.* Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones on DNA. Bioconjugate Chem. 2020, 31(12), 2712-2718. 5. Ding, Y.;* Chai, J.; et al. Development and Synthesis of DNA-Encoded Benzimidazole Library. ACS Comb. Sci. 2018, 20(5), 251-255. 6. Ding, Y.;* DeLorey, J. L.; Clark, M. A. “Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides”, Bioconjugate Chem., 2016, 27(11), 2597-2600. 7. Ding, Y.;* Franklin, G. J.; et al. “Design and Synthesis of Bi-Aryl DNA-encoded Libraries”, ACS Comb. Sci., 2016, 18, 625-629. 8. Ding, Y.;* O’Keefe, H.; et al. “Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-encoded Library Technology (ELT)” ACS Med. Chem. Lett., 2015, 6, 888–893. 9. Clark, M. A.; et al “Design, Synthesis and Selection of DNA-Encoded Small-molecule Libraries” Nat. Chem. Bio. 2009, 5, 647-654. Patents: 1. Ding, Y. PCT Int. Appl. (2010), WO 2010085246 2. Ding, Y.; Thalji, R. K.; Marino, J. P. PCT Int. Appl. (2009), WO 200949157. 3. Ding, Y.; Thalji, R. K.; Marino, J. P. PCT Int. Appl. (2009), WO 2009049165. 4. Ding, Y.; Longdregan, A. T.; Marino, J. P. PCT Int. Appl. (2009), WO 2009049154. 5. Ding, Y.; Marino, J. P.; Li, P.; Longdregan, A. T. PCT Int. Appl. (2008), WO 2008105968. Specialties: DNA-encoded library technology, synthetic chemistry, medicinal chemistry, combinatorial chemistry, high-throughput screening, drug discovery