Michael Duffey Email & Phone Number | Research in my laboratory concerns neurotransmitter and hormone-mediated anion secretion by gastrointestinal secretory tissues, like intestinal crypts and liver and pancreatic ducts, and airway. I am determining the mechanisms that regulate the basolateral membrane K+ channel, KCNQ1, in anion secretion because these channels play a critical role in secretion by maintaining membrane potential as a driving force for anion exit across the apical cell membrane. Characterization of KCNQ1 K+ channels will help us to understand and remedy defects in anion secretion, especially in diseases like cystic fibrosis. I use electrophysiological techniques, including Ussing chambers and patch-clamp, and Fura-2 flourescence techniques. I am also studying the mechanisms by which K+ channel antagonists (e.g., Zn2+) block KCNQ1 channels so that anti-secretory, anti-diarrheal drugs can be developed. I have past experience determining the mechanisms by which neurotransmitters regulate K+ channels via inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release transduction pathways.

Michael Duffey

Research in my laboratory concerns neurotransmitter and hormone-mediated anion secretion by gastroin...
Buffalo, New York, United States

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Michael Duffey’s Email duffey@buffalo.edu

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Michael Duffey’s Location Buffalo, New York, United States

Michael Duffey’s Current Industry University At Buffalo School Of Medicine And Biomedical Sciences

Michael Duffey’s Prior Industry University Of Buffalo School Of Medicine And Biomedical Sciences | Department Of Physiology School Of Medicine University Of Pittsburgh | United States Air Force

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Work Experience

University At Buffalo School Of Medicine And Biomedical Sciences

Professor of Physiology and Biophysics

1993-01-01 00:00:00 - Present

University Of Buffalo School Of Medicine And Biomedical Sciences

Assistant Professor of Physiology

1979-01-01 00:00:00 - 1985-01-01 00:00:00

Department Of Physiology School Of Medicine University Of Pittsburgh

Postdoctoral Fellow (S.G. Schultz, Mentor)

1977-01-01 00:00:00 - 1979-01-01 00:00:00

United States Air Force

Second Lieutenant - Captain

1969-01-01 00:00:00 - 1973-01-01 00:00:00

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FAQ About Michael Duffey

Michael Duffey is located at
Buffalo, New York, United States

Michael Duffey is a Research in my laboratory concerns neurotransmitter and hormone-mediated anion secretion by gastrointestinal secretory tissues, like intestinal crypts and liver and pancreatic ducts, and airway. I am determining the mechanisms that regulate the basolateral membrane K+ channel, KCNQ1, in anion secretion because these channels play a critical role in secretion by maintaining membrane potential as a driving force for anion exit across the apical cell membrane. Characterization of KCNQ1 K+ channels will help us to understand and remedy defects in anion secretion, especially in diseases like cystic fibrosis. I use electrophysiological techniques, including Ussing chambers and patch-clamp, and Fura-2 flourescence techniques. I am also studying the mechanisms by which K+ channel antagonists (e.g., Zn2+) block KCNQ1 channels so that anti-secretory, anti-diarrheal drugs can be developed. I have past experience determining the mechanisms by which neurotransmitters regulate K+ channels via inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release transduction pathways.

Michael Duffey currently works in the University At Buffalo School Of Medicine And Biomedical Sciences |

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Michael Duffey has prior
experience in the following industries:
University Of Buffalo School Of Medicine And Biomedical Sciences | Department Of Physiology School Of Medicine University Of Pittsburgh | United States Air Force

Michael Duffey has the following professional experience:
University At Buffalo School Of Medicine And Biomedical Sciences | University Of Buffalo School Of Medicine And Biomedical Sciences | Department Of Physiology School Of Medicine University Of Pittsburgh | United States Air Force